Biostatistician Cover Letter Examples & Writing Guide

Dear Hiring Manager, I am writing to express my strong interest in the Senior Biostatistician position in Oncology at Pfizer. With a PhD in Biostatistics and 6 years of experience in oncology clinical trial design and analysis, I am excited to contribute to Pfizer's transformative cancer research programs. At Merck, I have successfully: • Led statistical design and analysis for 5 Phase II/III oncology trials including adaptive designs • Developed innovative survival analysis methods for immuno-oncology combination studies • Collaborated with regulatory teams on FDA submission packages with successful approval outcomes • Mentored junior biostatisticians and statistical programmers on oncology-specific methodologies • Published 8 papers on adaptive trial designs and contributed to ICH E9(R1) addendum discussions Pfizer's commitment to oncology innovation and scientific rigor deeply inspires me. I am particularly drawn to your basket trial designs and precision medicine approaches in cancer. Thank you for considering my application. I look forward to discussing how my biostatistics expertise can advance Pfizer's oncology pipeline. Sincerely, Dr. Jennifer Chen

Dear Hiring Manager, I am excited to apply for the Mathematical Statistician position in the Division of Biometrics at FDA CDER. With a PhD in Biostatistics and 5 years of pharmaceutical industry experience, I am passionate about applying statistical science to protect public health through rigorous drug evaluation. At Bristol-Myers Squibb, I have: • Served as lead statistician on 8 regulatory submissions gaining insight into FDA review process • Developed expertise in adaptive designs, multiplicity adjustments, and missing data handling • Collaborated with regulatory affairs on pre-submission meeting preparations and responses • Authored statistical sections for NDAs, BLAs, and supplemental applications • Contributed to industry working groups on estimands and real-world evidence methodology The FDA's mission to protect public health through scientific evidence deeply resonates with me. I am eager to apply my industry perspective to ensure rigorous evaluation of new therapies. I would welcome the opportunity to discuss how my experience can contribute to FDA's regulatory science mission. Best regards, Dr. Michael Park

Dear Hiring Manager, I am writing to apply for the Biostatistician position in Early Development at Genentech. With a PhD in Statistics and 4 years of experience in Phase I/II oncology trials, I am eager to contribute to Genentech's innovative approach to early clinical development. At Novartis, I have successfully: • Designed dose-finding studies using model-based approaches including CRM and BLRM • Developed pharmacokinetic/pharmacodynamic models supporting dose selection decisions • Led Bayesian adaptive trial designs improving efficiency of early development • Collaborated with translational scientists on biomarker strategy and analysis • Programmed R Shiny applications for real-time monitoring of dose-escalation trials Genentech's scientific culture and commitment to innovative trial design deeply attract me. I am particularly excited about early development statistics and the opportunity to shape clinical programs from inception. Thank you for considering my application. I look forward to discussing how I can contribute to Genentech's early development. Sincerely, Dr. Sarah Williams

Dear Hiring Manager, I am excited to apply for the Principal Biostatistician position at IQVIA. With 8 years of biostatistics experience across therapeutic areas and a track record of client leadership, I am passionate about delivering statistical excellence to advance drug development. At Parexel, I have: • Led statistical teams on 20+ Phase II-IV clinical trials across oncology, CNS, and cardiovascular • Served as client-facing lead biostatistician managing sponsor relationships and expectations • Developed statistical analysis plans and TLF specifications meeting regulatory requirements • Mentored team of 10 biostatisticians on methodology and regulatory best practices • Contributed to business development through proposal writing and capability presentations IQVIA's scale and commitment to innovation in clinical development attract me. I am eager to lead statistical delivery while contributing to IQVIA's methodological excellence. I would welcome the opportunity to discuss how my leadership can strengthen IQVIA's biostatistics organization. Best regards, Dr. Robert Thompson

Dear Hiring Manager, I am writing to express my interest in the Biostatistician position supporting Vaccines at Moderna. With a PhD in Biostatistics and 4 years of infectious disease clinical trial experience, I am passionate about advancing Moderna's revolutionary vaccine platform through rigorous statistical science. At GSK Vaccines, I have successfully: • Designed and analyzed Phase III vaccine efficacy trials with adaptive interim analyses • Developed correlates of protection analyses supporting immunobridging strategies • Implemented multiplicity-adjusted analysis methods for complex vaccine trial endpoints • Collaborated with immunologists on vaccine response modeling and prediction • Contributed to regulatory submissions for pediatric and older adult vaccine indications Moderna's innovative mRNA platform and ambitious vaccine pipeline deeply inspire me. I am particularly excited about contributing to next-generation vaccine development beyond COVID-19. Thank you for considering my application. I look forward to discussing how my vaccine statistics expertise can support Moderna's mission. Sincerely, Dr. Emily Rodriguez

Dear Hiring Manager, I am excited to apply for the Biostatistician position in the Clinical Trials Office at Memorial Sloan Kettering Cancer Center. With a PhD in Biostatistics and 5 years of academic oncology research experience, I am dedicated to advancing cancer treatment through rigorous statistical methodology. At Dana-Farber Cancer Institute, I have: • Designed 30+ investigator-initiated oncology trials in collaboration with clinical investigators • Developed novel endpoints and analysis methods for immune-oncology combination trials • Led statistical analysis for high-impact publications in NEJM, JCO, and Lancet Oncology • Taught biostatistics courses to clinical fellows improving statistical literacy • Obtained NIH funding as co-investigator on R01 grants for methodology development MSK's leadership in cancer research and commitment to statistical innovation deeply inspire me. I am particularly drawn to collaborating with world-renowned investigators on practice-changing trials. I would welcome the opportunity to discuss how I can contribute to MSK's clinical research mission. Best regards, Dr. Lisa Park

Dear Hiring Manager, I am writing to apply for the Associate Biostatistician position at Biogen. With a Master's degree in Biostatistics and 2 years of pharmaceutical experience, I am eager to grow my career at a company pioneering treatments for neurological diseases. At a mid-size pharmaceutical company, I have: • Supported statistical analysis for Phase II CNS trials under senior biostatistician guidance • Programmed analysis datasets and tables, listings, and figures using SAS • Contributed to statistical analysis plans and performed quality control reviews • Developed skills in longitudinal data analysis relevant to neurology trials • Participated in cross-functional study teams representing biostatistics function Biogen's focus on neurological diseases and commitment to scientific excellence attract me. I am particularly interested in learning from experienced biostatisticians while contributing to meaningful research. Thank you for considering my application. I look forward to discussing how I can contribute to Biogen. Sincerely, Amanda Chen

Dear Hiring Manager, I am excited to apply for the Biostatistician position supporting Genetic Medicines at Regeneron. With a PhD in Biostatistics and 3 years of gene therapy clinical trial experience, I am passionate about statistical innovation to advance transformative genetic therapies. At Spark Therapeutics, I have: • Designed gene therapy trials addressing unique challenges: small populations, durable endpoints • Developed statistical frameworks for single-arm trials with historical controls • Implemented Bayesian borrowing methods incorporating external data sources • Collaborated with translational scientists on biomarker and gene expression analyses • Contributed to regulatory strategy for accelerated approval pathways Regeneron's genetics-centered approach and diverse genetic medicine pipeline deeply inspire me. I am particularly drawn to the statistical challenges of developing curative therapies. I would welcome the opportunity to discuss how my gene therapy statistics experience can advance Regeneron's mission. Best regards, Dr. Kevin Liu